Symposium

NEW DIRECTIONS IN TRANSCUTANEOUS BLOOD GAS MONITORING

SYMPOSIUM AGENDA

Date: October 31^st, 2023

Location: Higgins House,100 Institute Road, Worcester, MA, 01609. On the map

RSVP by October 24^th: Link The online stream link will be available for the lecture session. The Poster session will be only in person.

8:30–9:00	Registration
Morning Session – Online and In Person Session
09:00–09:10	John A. McNeill – Dean of Engineering (Worcester Polytechnic Institute)	Opening Remarks
Lecture Session
09:10–09:50	Lawrence Rhein – Chair of the Pediatrics Department (University of Massachusetts Chan Medical School)	Non-invasive respiratory physiologic data assessment to improve clinical practice
09:50–10:30	Oluf Dannevang – Head of R&D (Radiometer Inc.)	Transcutaneous O2/CO2 measurements: Why are they important, why aren’t they used more, and how should a future TC sensor look like
10:30–11:10	Foroohar Foroozan – Senior Manager in Digital Healthcare Business Unit (Analog Devices Inc.)	ADI remote patient monitoring systems and data analytics
11:10 – 11:20	Coffee Break
11:20–11:40	Adam Alessio – Chair of the Biomedical Engineering Department (Michigan State University)	Image-driven AI for precision diagnostics and healthcare
11:40–12:20	David McManus – Chair of the Medical School (University of Massachusetts Chan Medical School)	Can AI save American healthcare?
12:20-13:00	Beth Beidleman – Research Physiologist (United States Army Research Institute of Environmental Medicine)	Advances in physiologic prediction of acute mountain sickness in unacclimatized lowlanders at high altitude
13:00-14:00	Lunch Break
Afternoon Session – In Person Session
14:00–14:10	Donald R. Brown – Head of Electrical and Computer Engineering Department (Worcester Polytechnic Institute)	Welcome Remarks
Introduction of the Poster Session
14:10–14:40	Ulkuhan Guler – Associate Professor in the Electrical and Computer Engineering Department (Worcester Polytechnic Institute) Bige Deniz Unluturk – Assistant Professor in Electrical and Computer Engineering and Biomedical Engineering Departments (Michigan State University)	Brilliant Engineering Solutions
Poster Session
	Poster Title		Presenter
14:40-17:00	Evaluating a Wearable Transcutaneous Oxygen Monitor Prototype in Human Subjects		Vladimir Vakhter
	Optimizing Transcutaneous Oxygen Measurement Sites on Humans		Burak Kahraman
	Power optimization for Luminescent Transcutaneous Oxygen Measurements		Parisa Saadatmand
	Impact of Motion Artifacts on Transcutaneous Oxygen Measurements		Ryan McSweeney
	Additively Manufactured Receiver Design for Wirelessly Powered Biomedical Applications		Amin Hazrati
	13.56 MHz Wireless Power Transfer System for Neonatal Vital Signs Monitoring		Miguel Gonzalez
	A Transcutaneous Carbon Dioxide Monitor Based on Time-Domain Dual Lifetime Referencing		Tuna Tufan
	Fast Lifetime Detection Techniques and Their Utilization in Developing a Transcutaneous Carbon Dioxide Monitoring Device		Isil Isiksalan
	Performance Analysis of a Flexible HPTS-Based Carbon Dioxide Sensor for Transcutaneous Blood Gas Monitoring		Kosti Pano
	Oxygen Transport Models for Transcutaneous Monitoring		Mohammed Almatrood
	Challenges in Signal Processing and Computational Modeling for Transcutaneous Blood Gas Sensors		Hakan Karli
17:00-18:00	Open Discussion

PRESENTERS BIO

	John A. McNeill was named the Bernard M. Gordon Dean of Engineering in June 2021. McNeill joined WPI in 1994 after nearly a decade in industry and served as the interim Dean of Engineering from September 2018 until being appointed Dean. A senior member of IEEE and a member of the American Society for Engineering Education, the National Academy of Inventors, and the Council for Undergraduate Research, McNeill received a bachelor’s degree in engineering sciences from Dartmouth College, an MS in electrical engineering from the University of Rochester, and a PhD in electrical engineering from Boston University. His PhD work was a collaboration with Analog Devices to develop design techniques to reduce noise in integrated oscillators used in telecommunication systems. He continues to maintain close ties to industry as founding director of the New England Center for Analog and Mixed Signal Design, a university-industry collaborative that conducts research on cutting-edge mixed signal (analog + digital) integrated circuits and systems. McNeill’s research interests include biomedical sensing, jitter (noise) in integrated oscillators, and digitally assisted calibration of analog-to-digital converters used in low-power sensor systems. Supported by funding from the National Science Foundation (including a 1997 CAREER Award, the NSF’s most prestigious award for young faculty), other federal agencies, and industry, his research has resulted in six patents and over 60 peer-reviewed papers and conference presentations. In 1999, McNeill received the WPI Board of Trustees’ Award for Outstanding Teaching and he has won the Eta Kappa Nu Outstanding Electrical Engineering Professor Award three times (in 2000, 2008, and 2013). In 1995 he received the Joseph S. Satin Distinguished Fellowship in Electrical Engineering at WPI. In 2007 he was one of the two inaugural recipients of WPI’s Chairman’s Exemplary Faculty Prize, which honors outstanding faculty members for excellence “in all relevant areas of faculty performance.” McNeill has served as a research and project advisor to numerous graduate and undergraduate students, often emphasizing design of cutting-edge mixed (analog + digital) integrated circuits and systems.
	Lawrence Rhein, MD, MPH Lawrence Rhein, MD, MPH received the B.S. degree in biology from Harvard University, Cambridge, MA, USA, in 1992, the M.D. degree from the Perelman School of Medicine, the University of Pennsylvania, Philadelphia, PA, in 1996, and the MPH degree from Harvard University School of Public Health, Boston, MA, USA, in 2015. He did his residency in Pediatrics at the Boston Children’s Hospital. He is dual board-certified in Newborn Medicine and Pediatric Pulmonology. He is an Associate Professor with the UMass Medical School and the Department Chair of Pediatrics at UMass Memorial Medical Center (UMMMC). Additionally, he is the Director of the Center for Healthy Infant Lung Development (CHILD Clinic) at UMMMC, and his research interests include chronic lung disease of prematurity and long-term outcomes of preterm infants.
	Oluf Dannevang is R&D Principal at Radiometer Medical ApS in Copenhagen and specializes in Non-Invasive Monitoring & New Technologies. He holds a BSc. in E.E and are a Diploma Engineer with over 36 years of experience in medical device development. Their primary focus includes transcutaneous monitoring, vital sign monitoring, defibrillators, IVD blood gas instruments and sensors, as well as single use/disposable devices. They are passionate about advancing new sensor technologies to enhance the capabilities of healthcare professionals, ultimately saving lives and improving patient care.
	Foroohar Foroozan received her Ph.D. degree in computer science and engineering from York University, Toronto, Canada in 2011. She has been with the digital healthcare business unit at Analog Devices since 2015. Currently, she is a senior manager of research science engineering, supervising a team of signal processing and machine learning engineers focused on developing algorithms (both embedded and cloud) for remote patient monitoring systems. She was a postdoctoral fellow at Sunnybrook research institute working on 3D super-resolution ultrasound imaging for brain vascular mapping from 2012 to 2013. She was also a postdoc and a lecturer at the University of Ontario Institute of Technology, teaching both graduate and undergraduate courses from 2011 to 2013. She is also a senior member of the IEEE and a licensed professional engineer of Ontario, Canada.
	Adam Alessio is a professor in the departments of Computational Mathematics, Science, and Engineering (CMSE), Biomedical Engineering (BME), and Radiology. He is currently serving as the Interim Chair of the Department of Biomedical Engineering. His research is focused on non-invasive quantification of disease through advanced imaging algorithms and integrated data analysis. Prior joining MSU, Dr. Alessio was a professor of Radiology at the University of Washington.  He received his Ph.D. in Electrical Engineering at the University of Notre Dame and post-doctoral training in nuclear medicine physics at the University of Washington. He is the author of over 70 peer-reviewed publications, holds 6 patents, and has grant funding from the National Institutes of Health and the medical imaging industry to advance non-invasive cardiac and cancer imaging.
	David McManus, MD, ScM is a clinical and research cardiologist and cardiac electrophysiologist at the University of Massachusetts Chan Medical School (UMass Chan). He is also the Chair of the Department of Medicine at UMass Chan. He served as the Department of Medicine’s Vice Chair for Clinical Affairs and principal investigator for Rapid Acceleration of Diagnostics (RADx grant) where he brought innovative ideas and strategies for testing amidst the coronavirus pandemic. He also helped lead the UMass Memorial Health (UMMH) redeployment of health professionals during the coronavirus crisis. Dr. McManus serves as Chief of the Section of Connected Cardiovascular Healthcare and Director of the Anticoagulation Service and Atrial Fibrillation Treatment Program at UMMH. He has led successful multi-site observational cohort studies (e.g., SAGE-AF) and clinical trials using point-of-care technologies (e.g., VITAL-AF, PULSEWATCH). He has served in leadership roles on national research, quality, and patient advocacy committees for the Heart Rhythm Society, the American College of Cardiology, and the American Heart Association. For his work within the Cardiovascular Research Network, he received the HMO Research Network Early Career Investigator Award. In 2012, he received a UMass Chan Clinical Scholar (K12) Award to understand mechanisms underlying cardiac remodeling and arrhythmia. Dr. McManus also received the Joan and Douglas Zipes Award for the most impactful manuscript published in Heart Rhythm for his work describing his primary findings. He was selected as a Dr. Marcellette Williams Scholar in 2018. In 2021, he was invested as the Richard M. Haidack Professor of Medicine, an endowed professorship, appointed founding director of the new Program in Digital Medicine and appointed President-Elect of the American Heart Association’s Board of Directors.
	Dr. Beth Beidleman, over her 32-year government career, has served as a subject matter expert in the field of high-altitude physiology, physiologic monitoring, and environmental multi-omics research. She has executed a high visibility Department of Defense (DOD) Science and Technology Program that impacted key policy and practice changes in the US Army. Key scientific areas of research included the first studies on women at altitude, the impact of intermittent altitude exposures for preacclimatization, updated guidance on staging at moderate altitude, time-course of altitude deacclimatization, first quantitative models of health and performance at altitude, acceleration of jet-lag recovery using hypoxic gases, and physiologic and molecular predictors of environmental injuries. She has secured over $15 million in grant funding resulting in the transition of products to the US Army such as the Altitude Readiness Management System smart-phone application, Hidalgo Equivital FDA-certified physiological status monitor and world’s largest Mountain Medicine Database. She has published over 52 manuscripts, 20 technical reports, 120 abstracts, 27 protocols as a principal or co-investigator, filed five patent applications, established many collaborations with outside researchers, received numerous Department of Defense Medals for Civilian Service, and been awarded the 2014 Association of Military Surgeons Prize for exemplary published research, the 2011 Army Research and Development Achievement Award for Technical Excellence (1% of DOD scientists selected), the Boston University Lifetime Achievement Award and US Army Meritorious Service Award. She serves on numerous government and civilian committees, has served as an invited speaker in over 20 national and international symposiums and is an editorial board member for High Altitude Medicine and Biology.
	Rick Brown is currently the Weston Hadden Endowed Professor and Head of the Department of Electrical and Computer Engineering at WPI. He received a BS and MS in electrical engineering from the University of Connecticut and received his PhD degree in electrical engineering from Cornell University. From 1992-1997, he was with General Electric Electrical Distribution and Control. Since August 2000, he has been with the Department of Electrical and Computer Engineering at WPI. He also held an appointment as a Visiting Associate Professor at Princeton University and an appointment as a Program Director at the National Science Foundation.
	Bige Deniz Unluturk is an assistant professor in both the Department of Electrical & Computer Engineering and Biomedical Engineering at Michigan State University since Fall 2021. In between August 2020- August 2021, she was a Postdoctoral Research Associate in Dr. Chris Contag’s Lab at Institute of Quantitative Health Science and Engineering, MSU. Before joining MSU, she received her Ph.D. degree in Electrical and Computer Engineering from the Georgia Institute of Technology, Atlanta, GA, in August 2020. In 2013, she received her M.Sc. degree from Koc University, Istanbul, Turkey. In 2011, she graduated from Electrical and Electronics Engineering at Middle East Technical University, Ankara, Turkey. Her research is in the areas of modeling and analysis of biological transport processes with a focus on molecular communications (MC) Molecular Communications and Internet of Bio-NanoThings, and their applications to healthcare.
	Ulkuhan Guler is an associate professor of Electrical and Computer Engineering and director of the Integrated Circuits and Systems (ICAS) Laboratory at Worcester Polytechnic Institute (WPI), MA, USA. Before joining WPI in 2018, Dr. Guler was a postdoctoral researcher at Georgia Tech, GA, USA. She received her B.Sc. degree in Electronics and Telecommunication Engineering from the Istanbul Technical University, Istanbul, Turkey, her M.E degree in Electronics Engineering from the University of Tokyo, Tokyo, Japan, and her Ph.D. degree from Bogazici University, Istanbul, Turkey. Her research interests lie in the broad area of circuits and systems, and her primary area of interest is analog/mixed-signal integrated circuits. More specifically, she is interested in the circuit design of sensing interfaces, bioelectronics, energy harvesting and wireless power transmission systems, and security for applications in healthcare. Recently, her research interest has focused on determining how electronic interfaces can be engineered along with biosensors to facilitate the creation of wireless wearable sensors that measure physiological parameters in the human body. She is the recipient of the 2022 NSF CAREER award and the Interstellar Initiative Young Investigator award. She is a senior member of IEEE. She serves as an associate editor for several IEEE journals, including IEEE SSC-L, IEEE TBioCAS, and IEEE TCAS: II. Dr. Guler co-authored three book chapters. She also serves as a TPC member of the IEEE CICC and IEEE BioCAS conferences. In addition, she is a member of several solid-state circuits and circuits and system communities, including the Women in Circuits Committee.